Role of MEK1 in TLR4 Mediated Signaling
نویسندگان
چکیده
The highly evolutionary conserved mitogen activated protein kinase kinases 1 and 2 (MEK1/2), are known as upstream protein kinases that phosphorylate ERK1and ERK2. There are two distinct gene isoforms Mek1 and Mek2. While MEK1 and MEK2 show high homology in their kinase domains, their N termini are significantly divergent. The differential role of MEK1 and MEK 2 in cellular signaling in inflammation has not been widely investigated. In this commentary, we address new insights gained in recent years and comment on emerging work using a genetic approach to address the role of MEK1 in TLR4 mediated signaling as well as possible alternative pathways that lead to ERK activation in macrophages independent of MEK1.
منابع مشابه
P 147: Role of Sparstolonin B in Intracerebral Hemorrhage-Induced Inflammatory Brain Injury: Blocking the Formation of TLR2/TLR4 Heterodimer
Intra-cerebral hemorrhage (ICH) is a particularly severe type of stroke accounting for 10–15 % of all strokes and is associated with a mortality rate of 30–50%. Neuroinflammation contributes to ICH-induced secondary brain injury and understanding the mechanisms causing neuroinflammation can be helpful to find new treatments of ICH. Recent studies demonstrated that toll like receptor...
متن کاملTLR2 and TLR4 Signaling Pathways and Gastric Cancer: Insights from Transcriptomics and Sample Validation
Background: Pattern recognition receptors, especially toll-like receptors (TLRs), as the first line of defense for pathogen detection, were found to be associated with H. pylori infection and gastric cancer (GC). However, the expression levels of TLRs, i.e. TLR2 and TLR4, as the main receptors sensed by H. pylori, still remain largely ambiguous. We aimed to investigate the patterns of key tra...
متن کاملP-246: Gene Variation of TLR4 in Patients with Endometriosis
Background: Endometriosis, defined as the presence of endometrial tissue outside of the uterus, is an estrogen-dependent chronic inflammatory condition associated with degrees of pelvic pain and infertility. Toll-like receptors play a key role in immune response, by regulating inflammatory reactions and activating adaptive immune response to eliminate infectious pathogens and cancer debris. Pol...
متن کاملActivation of Wnt signaling reduces high-glucose mediated damages on skin fibroblast cells
Objective(s): High-glucose (HG) stress, a mimic of diabetes mellitus (DM) in culture cells, alters expression of a large number of genes including Wnt and NF-κB signaling-related genes; however, the role of Wnt signaling during HG-mediated fibroblast damage and the relationship between Wnt and NF-κB signaling have not been understood. In this study, we aimed to investigate the ffects of Wnt sig...
متن کاملFiltered Kombucha Tea Rings the Bell for TLR2, TLR4, MYD88, and Dectin-1 in Mice Model of Colitis
Background and objectives: TLR2, TLR4, and Dectin-1 (Clec7) are pattern recognition receptors (PRRs) expressed by intestinal epithelia cells and MYD88 is a signaling molecule of TLR2 and TLR4. They warn immune system about the presence of invading pathogens promoting initiation of inflammatory response. Because of colonic cancer risk, therapy of intestinal inflammation is of h...
متن کامل